現象数理セミナー

第1回 現象数理セミナー(2008年度)

 

タイトル : Modeling lung branching morphogenesis

講演者 : 三浦 岳 氏(京都大学大学院医学研究科・JSTさきがけ研究員)

日時 : 2008年4月24日(木) 16:30 ~ 17:30

場所 : 明治大学生田校舎・中央校舎6階・0605室(メディアゼミ室2)

 

要旨・Lung branching morphogenesis has been extensively studied in developmental biology. Although numerous molecules has been shown to be involved in this process, how the interaction of these molecules result in branch structure is not well understood. On the other hand, abstract model for branching morphogenesis has been formulated in applied mathematics and its behavior is well understood. However, the model has not been utilized well in developmental biology. In this talk I will describe a simple in vitro experimental system which retain the key feature of lung branching morphogenesis. We established biologically realistic models which can reproduce the pattern formation in vitro, and experimentally verified the models. Both models could make experimentally testable predictions, and experimental results showed the validity of the models. Next, to extrapolate the result to in vivo situation, we used the chick lung as a experimental system because it generates both branch and cyst tructure simultaneously during development. We made two experimentally testable hypothesis on cystbranch difference from previous models, and experimentally verify them using fluorescentlylabeled signaling molecules.

 

 

 

 

 

 

 

 

自由参加です。
皆様のお越しをお待ちしております。 

 

明治大学先端数理科学インスティテュート ・ 現象数理部門(世話人:三村昌泰、上山大信、若野友一郎)


この研究会は,科学研究費補助金 基盤研究(S) 『非線形非平衡反応拡散系理論の確立』 代表者 : 三村昌泰(明治大学理工学部)の援助を受けております。

 

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